Really a good one. Naked Lunch is as well, and while I'm a great admirer of Burroughs I think he's read for all the wrong reasons (drug culture, the famous obscenity trial). On that note, I'd add Fear & Loathing In Las Vegas, one of the saddest and most literary books I've read, and largely unappreciated as anything except an in the trenches report from drug addiction and burnout.
I'm curious why? You don't think HoL stands on its own without the layout/writing style, or?