A couple things:
-Live for yourself. I know this is a canned phrase, but it means something! Stick up for yourself, and try to change the world to be more hospitable to who you are, instead of changing yourself to be who the world wants you to be. This will be difficult, but will give your life more meaning.
-Learn to pick something you find interesting, and just stick with it and DO IT. Surely there must be SOMETHING you like. Do you like manga? Draw manga. Not good at drawing, you say? Then learn. Practice. You may not be any good now, but if you learn to love the creation process for itself, you will find some years down the road that all the struggle has paid off, you really are pretty good at drawing, and your life has more meaning than it previously did - more direction. Piro (Fred Gallagher) is an excellent example of a shy, self-loathing artist who really sucked at drawing - but he stuck with it, and grew and grew as an artist until Megatokyo, HIS creation, finally became one of the most popular comics on the Web. This attitude can be applied to anything.

That's all I can think of for now. Good hunting!